NHLBI stem cell consortium provides new insights into genetics of heart disease, other conditions

April 11, 2017 -

A group of NIH-funded scientists has published the first studies using the largest, most diverse stem cell collection of its kind ever made available to researchers. The results provide fresh insights into the genetic underpinnings of common conditions such as cardiovascular disease, high blood pressure, diabetes, and sickle cell disease, which take a heavy toll on American lives and resources.

In the future, discoveries from these studies of adult stem cells could lead to new ways to diagnose and treat disease, the researchers say. The first 11 studies resulting from this collaborative effort from multiple U.S. institutions appear in the journals Cell Stem Cell, Stem Cell Reports, and EBioMedicine, which are published by Cell Press.

In 2011, the National Heart, Lung, Blood Institute (NHLBI), part of NIH, convened its Next Generation Genetic Association Studies (NextGen) Consortium with the goal of using induced pluripotent stem cells (link is external) (iPS cells) to better understand how complex genetic changes affect heart, lung, and blood cells. More than 1,000 iPS cell lines were obtained from more than 1,000 volunteers of different genders and ethnic backgrounds, making it one of the one of the most diverse stem cell collections ever studied. That diversity, the researchers note, ultimately will prove useful in helping reduce health disparities based on gender and ethnicity.

Read more: https://www.nih.gov/news-events/news-releases/nhlbi-stem-cell-consortium-provides-new-insights-into-genetics-heart-disease-other-conditions

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